PRLR and breast cancer: Moreover, PRLR-high tumors in patients who were treated with radiotherapy and experienced a breast cancer event within 5 or 10 years displayed the significant enrichment of DNA double-strand break responses (Normalized Enrichment Score (NES) BFCI ≤ 5 years= 1.71, Padj = 0.004; NES BFCI ≤ 10 years= 1.61, Padj = 0.017) and base excision repair pathways (NES BFCI ≤ 5 years= 1.90, Padj = 0.002; NES BFCI ≤10years = 1.91, Padj = 0.001).