A number of the residual disease markers had been previously associated with CTCL cells including four highly diagnostic genes we and others described previously as distinguishing the normal and malignant cells, including Gata3, PLS3, and DUSP4 [6,7]; the microtubule-associated GTPase DNM3 [61], the c-MYB protooncogene [62]; and the ephrin receptor EPHA4 [63]. Here, PLS3 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.