While much pancreatic cancer research focuses on the four most frequently mutated genes (KRAS, TP53, CDKN2A, and SMAD4), this review highlights the significant, but less-understood roles of further tumour suppressors, such as PTEN, KDM6A, and ARID1A in PDAC. The gene discussed is KDM6A; the disease is pancreatic neoplasm.