However, immunohistochemical analyses of the abundance of the MAP2K4 protein in pancreatic cancer tissue samples have provided somewhat conflicting data:some studies have reported higher levels of MAP2K4/MKK4 expression in PDAC tissue than in healthy pancreatic ducts, while others have reported a loss of expression [108,109,110,111]. The gene discussed is MAP2K4; the disease is familial pancreatic carcinoma.