Other notable examples being explored include H101, an oncolytic adenovirus targeting malignant ascites; HF10, an attenuated, replication-competent mutant strain of Herpes Simplex Virus (HSV) type 1 in locally advanced pancreatic cancer; and Ad5-yCD/mutTKSR39rep-hIL-12, an oncolytic adenovirus expressing cytosine deaminase and thymidine kinase to convert non-toxic pro-drugs to DNA synthesis inhibitors and human IL-12 to promote responses by NK cells, Th1 CD4+ T cells, and cytotoxic CD8+ T cells [249,250]. This evidence concerns the gene CD4 and familial pancreatic carcinoma.