A series of studies performed in Dr Rhee’s Lab have demonstrated that, on the one hand, PTEN invalidation in intestinal epithelial cells increased mouse sensitivity to Salmonella Typhimurium infection [59], and on the other this invalidation decreases the abundance of Akkermansia muciniphila, a phylia that degrades mucin and might trigger chronic intestinal inflammation [60]. This evidence concerns the gene MUC5AC and inflammatory response.