These findings suggest enhanced therapeutic efficacy of the drug-loaded liposomes in the U251/PEG3-FTH1 and U251/PEG3-bFGF2 5′UTR-FTH1-WPRE groups compared to the U251/PEG3-FTH1 group; the U251/PEG3-bFGF2 5′UTR-FTH1-WPRE group exhibited a slightly stronger tumor-suppressive effect. Here, FTH1 is linked to neoplasm.