-Cysteine enables cancer cells to survive in hypoxic conditions-N-acetylcysteine supplementation accelerates tumor progression and reduces survival in transgenic lung cancer models-Cysteine deficiency inhibits ovarian clear cell carcinoma-Inhibition of cysteine transporter induces ferroptosis and boosts cisplatin′s cytotoxic effects in ovarian cancer cells-Blocking xCT increases sensitivity of HeLa cells to chemotherapies and impedes the growth of colorectal cancer-Cysteine depletion induces death in pancreatic tumor cells. Here, SLC7A11 is linked to ovarian clear cell cancer.