In another study, a VACV encoding a tandem of Fms-related tyrosine kinase 3 ligand (Flt3l) and OX40L genes completely eliminated A20 lymphoma tumors and significantly delayed the development of spontaneous tumors in the MMTV-PyMT mouse model of triple-negative breast cancer (TNBC) [168]. This evidence concerns the gene FLT3LG and triple-negative breast carcinoma.