IL6 and acute lymphoblastic leukemia: Furthermore, although CD19-ReTARGTPR, blinatumomab, and CD19 CAR T cells induced comparable lysis of B-ALL SEM cells (Figure 4D), CD19-ReTARGTPR elicited significantly lower levels of secretion of several core proinflammatory cytokines involved in CRS, most notably TNFα, TNFβ, and IL6 (Figure 4E and Figure A2).