Furthermore, although CD19-ReTARGTPR, blinatumomab, and CD19 CAR T cells induced comparable lysis of B-ALL SEM cells (Figure 4D), CD19-ReTARGTPR elicited significantly lower levels of secretion of several core proinflammatory cytokines involved in CRS, most notably TNFα, TNFβ, and IL6 (Figure 4E and Figure A2). This evidence concerns the gene TNF and acute lymphoblastic leukemia.