Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a critical mediator of CBM (CARD11-BCL10-MALT1) complex-driven NF-κB signaling, which is constitutively activated in CLL and contributes to BCR pathway-independent survival [120]. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.