In chronic myeloid leukemia, PD-1/PD-L1 is highly expressed by immunosuppressive myeloid-derived suppressor cells (MDSCs), which aids in immune evasion, and PD-L1 blockade increases IL-2 release but does not restore full T-cell proliferation [50]. The gene discussed is CD274; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.