ESR2 and neoplasm: The oestrogen receptors Erα and Erβ have been shown to be expressed in the exocrine tissue of the pancreas and might play a role in tumour growth, either inhibiting tumour growth directly, as suggested in vitro [10] and in research on rat models [12], or via a moderating effect similar to what has been shown for the carcinogenesis of breast, colorectal and ovarian cancers [48,49,50,51].