However, when combined with the therapeutic strategy of fusing the cytoplasmic domains of a CAR and CTLA4, harnessing CD28-mediated trogocytosis of CD80/86 may induce increased clonal expansion of CAR T cells effective against the tumor while decreasing CAR-mediated trogocytic acquisition of MHC peptides and thereby decreasing fratricide. Here, CD80 is linked to neoplasm.