MOD: Defined as the involvement of three or more organ systems, including but not limited to cardiovascular (e.g., CAL, MD), hematologic (e.g., granulocytopenia, anemia, thrombocytopenia), electrolyte disturbances (e.g., hyponatremia, hypokalemia), neurological (e.g., sterile meningitis, facial nerve palsy), respiratory (e.g., interstitial pneumonia), hepatic (e.g., elevated ALT), genitourinary (e.g., urethritis), musculoskeletal (e.g., arthritis), and macrophage activation syndrome (MAS). This evidence concerns the gene GPT and macrophage activation syndrome.