Similar HMGB1–TLR4–STAT3 interactions have been observed in CLP-induced septic lung injury models and LPS-stimulated BEAS-2B–THP-1 co-cultures [187].Ferroptosis inhibitors such as liproxstatin-1 not only preserved M2 macrophage populations but also attenuated tissue injury in erythroid Jak2V617F-driven iron-overload atherosclerosis and serum-transfer arthritis models [188,189]. The gene discussed is HMGB1; the disease is arthritic joint disease.