While most studies on SPP1 have focused on its role in cancers (e.g., hepatocellular, colorectal, and cervical carcinomas) [41], recent work by Freiholtz et al. [42] identified SPP1 as a critical mediator of epithelial–mesenchymal transition (EMT) in degenerative ascending aortic aneurysms. Here, SPP1 is linked to cancer.