KEAP1 and lung carcinoma: Pharmacological inhibition of the Nrf2/Kelch-like enoyl-CoA hydratase-associated protein 1 (Keap1) pathway by K-563, a natural compound derived from Streptomyces species, suppresses GSH biosynthesis and elevates intracellular ROS levels in lung cancer cells, suggesting that K-563 is a potential chemotherapeutic agent [13].