The altered expression and activity of SOD isoforms, manganese SOD (MnSOD), copper/zinc SOD (CuZnSOD), and extracellular SOD (ECSOD) as first-line antioxidant defense components are recurrent features observed in lung cancer, reflecting dysregulated redox homeostasis across tissue, cellular, and systemic levels [41,42]. This evidence concerns the gene SOD1 and lung carcinoma.