Signaling cascades, including Nuclear factor erythroid 2-Related Factor 2 (Nrf2)-Antioxidant Response Element (ARE) pathway and Mitogen-Activated Protein Kinase (MAPK)-Extracellular signal-Regulated Kinase (ERK), which are already dysregulated in Alzheimer’s disease, lead to prolonged neuroinflammation and neuronal stress [93]. Here, NFE2L2 is linked to early-onset autosomal dominant Alzheimer disease.