CXCL12 and neoplasm: Moreover, qPCR results showed a downregulation of β2-integrins (ΙΤGB2), receptors that are exploited by common skin pathogens to establish contact with host cells [43,44], and of C-X-C ligand motif chemokine 12 (CXCL12 or SDF-1), a chemokine with an important role in skin inflammation and inflammatory angiogenesis [45,46].