In a rodent model of stroke, treatment with chlorpromazine and promethazine reduced infarct size and neuronal damage through modulation of the protein kinase C delta (PKC-δ)/nicotinamide adenine dinucleotide phosphate oxidase/MnSOD pathway, confirming MnSOD’s involvement in pharmacological neuroprotection during ischemic injury [208]. This evidence concerns the gene SOD2 and Stroke.