In a triple-transgenic AD (3×Tg-AD) mouse model with cerebral microinfarcts, activation of protein kinase C epsilon (PKCε) improved memory and hippocampal vascular integrity, effects associated with increased MnSOD expression, suggesting that MnSOD contributes to both neurovascular and cognitive protection in AD complicated by vascular injury [217]. The gene discussed is SOD2; the disease is Alzheimer disease.