SOD2 and Parkinson disease: Additionally, inhibition of mixed-lineage kinase domain-like protein in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model decreased oxidative stress and dopaminergic neuronal death, in part by increasing MnSOD expression, further implicating MnSOD in limiting PD-associated neurodegeneration [214].