HMGB1 and bronchopulmonary dysplasia: The anti-inflammatory activities of KYC include decreasing neutrophil infiltration and MPO expression in the rat BPD lungs [146], reducing the expression of cyclooxygenases, TLR4, AGER, and extracellular HMGB1, oxidizing HMGB1, decreasing HMGB1 binding to PRRs [146], and attenuating ER stress [76], autophagy, and cellular senescence [31].