Hyperglycemia-mediated mitochondrial dysfunction has been correlated with the overproduction of ROS and impairments in Kelch-like ECH-associated protein 1 (Keap1) and Nuclear Factor (erythroid-derived 2-)-like 2 (Nrf2) mediators in diabetic retinopathies [20]. The gene discussed is KEAP1; the disease is Hyperglycemia.