Hyperglycemia-mediated mitochondrial dysfunction has been correlated with the overproduction of ROS and impairments in Kelch-like ECH-associated protein 1 (Keap1) and Nuclear Factor (erythroid-derived 2-)-like 2 (Nrf2) mediators in diabetic retinopathies [20]. Here, NFE2L2 is linked to diabetic retinopathy.