In line with this, the combination of polyphenol-rich antioxidants sourced from Aronia melanocarpa berries with CPAP therapy has shown synergistic benefits in the treatment of OSA by lowering the levels of proinflammatory cytokines, such as TNF-α and IL-6, which are commonly elevated in OSA patients [140]. The gene discussed is TNF; the disease is obstructive sleep apnea syndrome.