Conversely, treatment with C60 and C60(OH)24 resulted in a significant increase in Sirt1 expression in APP/PS1 mice relative to the control group (p = 0.0288, and p = 0.0454, respectively; Tukey’s test; Figure 7D), suggesting a potential restorative effect of fullerenes on Sirt1 levels in the Alzheimer’s disease model. This evidence concerns the gene APP and Alzheimer disease.