MTOR and premature menopause: For instance, curcumin protects ovarian granulosa cells in vivo by regulating AMPK/mTOR-mediated autophagy [37], and proanthocyanidins counteract 3-NPA-induced premature ovarian failure (POF) through the activation of SESTRIN2-NRF2 oxidative stress responses [38], while icariin alleviates cisplatin-induced POF by ameliorating oxidative damage via activating the NRF2/ARE pathway [39].