Although fission and fusion are often inversely regulated under physiological conditions [46], both our present findings and previous studies have shown that the expression levels of MFN2 and FIS1 are markedly decreased in kidneys of mice with hyperuricemic nephropathy and Cis-AKI, and this downregulation is more pronounced in NRF2-deficient mice [23]. The gene discussed is MFN2; the disease is acute kidney injury.