PRKN and Parkinson disease: Familial PD forms are associated with mutations in genes critical for mitochondrial dynamics and quality control (e.g., PARK2 encoding Parkin, PINK1) and lysosomal function or autophagy (e.g., GBA1 encoding β-glucocerebrosidase [36,67,68], PARK9 encoding ATP13A2) [57,69].