Among TRP channels, TRPM2 (Transient Receptor Potential Melastatin 2) emerges as particularly important due to its direct sensitivity to OS-generated molecules and its established role in promoting OS-related damage in numerous cardiovascular, neurodegenerative, and metabolic disease models [100,101,102,103,104,105,106,107]. This evidence concerns the gene TRPM2 and Other metabolic disease.