For example, studies on pancreatic β-cells (diabetes model) and neuronal cells (PD model) concurrently examined roles for NOX2, TRPM2, Ca2+, Zn2+, and Complex III (in PD model only) in lysosomal/mitochondrial damage and ROS amplification, demonstrating the circuit’s role in cell death [88,113]. This evidence concerns the gene CYBB and Parkinson disease.