ATP13A2 and Parkinson disease: Zn2+ chelation (TPEN): ↓ROS levels ↓MPP+-induced cytotoxicity [88].Zn2+ chelation (Clioquinol) in Lewy Bodies-injected mice:↓α-synuclein-associated degeneration [164].Post-mortem brains of PD patients:↑Zn2+ levels observed in SNpc [165].Genetic mutations in PARK9: ↑Mitochondrial Zn2+ in dopaminergic neurons ↑Mitochondrial damage [57,69].