Evidence for the unified mechanism depicted schematically in Figure 3 emerges from diverse cellular models of chronic stress: high glucose (diabetic stress mimic) on endothelial cells [112]; free fatty acids (metabolic stress mimic) on pancreatic β-cells [113]; Parkinsonian toxin (1-methyl-4-phenylpyridinium, MPP+) on neuroblastoma cells [112]; and oxidative stress (H2O2) on HEK-293 cells conditionally expressing TRPM2 channels [88,112]. This evidence concerns the gene TRPM2 and neuroblastoma.