NOX2 inhibition (chemical) in a cellular model: ↓MPP+-induced Ca2+ rise↓mtROS production↓Cell death [88].NOX2 inhibition (apocynin) in paraquat and 6-OHDA administered mice: ↓Cognitive deficits ↓Oxidative stress ↓Neuroinflammation [161,162].NOX2 KO in 6-OHDA administered mice: ↓Dopaminergic neuron loss [162].Post-mortem brains of PD patients:↑gp91phox expression in midbrain [163]. This evidence concerns the gene CYBB and Parkinson disease.