Initially, insulin resistance was induced in rats by feeding with a high-fructose diet for ten weeks, and the levels of glucose, insulin, glycosylated hemoglobin, HbA1c, total cholesterol, LDL-cholesterol, triglyceride, alanine transaminase (ALT), aspartate transaminase (AST), creatinine and uric acid increased in serum, accompanied by a decrease in glutathione and SOD levels. The gene discussed is INS; the disease is Insulin resistance.