In a later study, Sajadi et al. [140] investigated the effects of the ICV injection of insulin (5 mIU/5 μL) and the oral administration of cinnamon (200 mg/kg) extract on spatial memory and glucose transporter (GLUT) 1, 3, and 4 gene expressions in the hippocampus in an STZ-induced AD rat model; the behavior performance of rats in the Morris water maze test was improved in the group co-administered with CA extract and insulin injection, accompanied by the elevation of expressions of GLUT1, 3, and 4 genes in the hippocampal tissue. The gene discussed is INS; the disease is Alzheimer disease.