A reduction in serum rheumatoid factor, arthritis index, paw swelling, cartilage and bone erosion, as well as in cytokines including TNF-α, IL-1β, IL-6, IL-23, IL-17 and COX-2, was observed through the modulation of the NF-κB pathway in inflamed paw tissues, with both TCA and MTX showing a similar inhibition effect. Here, IL6 is linked to arthritic joint disease.