Compared to adipocytes without insulin resistance, the upregulated miRNA-320 and downregulated miRNA-26b, as well as GLUT4 expressions, in insulin-resistant 3T3L1 adipocytes were shown to be improved by all three treatments (CA-rich cinnamon extract, metformin, and their combination), suggesting that CA-rich cinnamon extract and metformin can restore the changes in miRNA expressions caused by insulin resistance, possibly via PI3K/Akt/GLUT4 or MAP kinase pathways (Figure 7A). The gene discussed is AKT1; the disease is Insulin resistance.