Also, the levels of netrin-1, DCC, UNC5B, receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) were increased, while TGF-β, cathepsin K, tartrate-resistant acid phosphatase (TRAP) and the receptor activator of nuclear factor kappa B (RANK) levels were suppressed in diabetes-induced OP rats in a dose-dependent manner, indicating that the osteoclast activity induced in diabetic rats can be inhibited by CA. This evidence concerns the gene TNFRSF11A and diabetes mellitus.