Apocynin (also termed acetovanillone, an organic compound structurally related to vanillin) reduces proteinuria in animals suffering from PAN by inhibiting NOX and therefore counteracting superoxide production in podocytes, as well as by countering FcRn-mediated albumin transport (FcRn or the neonatal fragment crystallizable [Fc] receptor plays a role in albumin turnover) [216]. The gene discussed is ALB; the disease is polyarteritis nodosa.