P78 peptide treatment not only prevented the development, but also the progression, of DN in the Ins2Akita murine diabetic model, as indicated by decreased albuminuria, decreased kidney macrophage recruitment, and inflammatory cytokines (kidney TNF-α, fibronectin, VEGFA and EGFR), reduced histological changes, and increased nephrin expression. The gene discussed is TNF; the disease is liver dysplastic nodule.