REN and hyperuricemia: There is a bidirectional relationship between hyperuricemia and renal function: While decreased renal function can cause hyperuricemia, hyperuricemia can also lead to renal failure by causing damage, scarring, and stone formation through endothelial dysfunction, activation of the renin-angiotensin system, hypertension, and accumulation of uric acid crystals in the kidneys [13,14].