This is important, as adenylyl cyclases (ACs), which synthesise cAMP, such as AC5 and AC6, are directly inhibited by higher Ca2+ concentrations, and in fact, the disruption of either AC5 and AC6 is known to slow ADPKD progression in mouse models [46,47]. The gene discussed is ADCY6; the disease is autosomal dominant polycystic kidney disease.