The interaction of PC1 with G-proteins regulates numerous pathways that have been implicated in ADPKD, including cell survival and proliferation via phosphatidylinositol 3- kinase (PI3K)–Akt and c-Jun N-terminal kinase (JNK)–activator protein 1 (AP1) [55,56], as well as Ca2+ signalling via phospholipase C and the activation of nuclear factor of activated T cells (NFAT) [57]. Here, PKD1 is linked to autosomal dominant polycystic kidney disease.