Numerous studies have implicated a multitude of molecular pathways that may contribute to ADPKD cyst initiation and progression, including cyclic adenosine monophosphate (cAMP), G-protein signalling, mechanistic target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK), and Wingless-related integration site (Wnt) [41]. The gene discussed is MTOR; the disease is autosomal dominant polycystic kidney disease.