This study aims to elucidate the expression patterns of key necroptotic and apoptotic proteins—including RIPK1, RIPK3, MLKL, A20, caspase-8, interleukin (IL)-1β, and IL-18—in critically ill pediatric and adult patients with sepsis, and to explore their correlation with clinical severity indices and patient outcomes, in comparison to controls. Here, TNFAIP3 is linked to Sepsis.