This study aims to elucidate the expression patterns of key necroptotic and apoptotic proteins—including RIPK1, RIPK3, MLKL, A20, caspase-8, interleukin (IL)-1β, and IL-18—in critically ill pediatric and adult patients with sepsis, and to explore their correlation with clinical severity indices and patient outcomes, in comparison to controls. This evidence concerns the gene IL1B and Sepsis.