While PCIS does not have well-defined diagnostic criteria due to the lack of specific symptoms and signs, it should be considered after cardiac injury if at least two out of following five criteria are satisfied: unexplained fever, chest pain suggestive of pericarditis or pleurisy, audible pericardial or pleural rubs, evidence of pericardial or pleural effusion, and/or elevated CRP levels [5]. This evidence concerns the gene CRP and Pleural effusion.