SERPINE1 and neoplasm: SASP-mediated tumor suppressive functions, such as the secretion of interleukin-6 (IL-6), interleukin-8 (IL-8), plasminogen activator inhibitor-1 (PAI-1), and insulin-like growth factor-binding protein 7 (IGFBP7), enhance senescence arrest in in vitro experiments [31].