IRAK2 and familial pancreatic carcinoma: However, all statins used increased the expression of the NF-κB pathway activator IRAK-2 in pancreatic cancer cells, and some statins affected the expression of some genes encoding TLRs known to modulate the expression of the gene encoding NF-κB as exemplified by the slight upregulation of TLR 4 expression by fluvastatin.