For example, Tanshinone IIA, which is extracted from the root of Salvia miltiorrhiza, has shown effects on RA-FLS because it has anti-inflammatory and pro-apoptotic properties and can regulate the protein related to apoptosis, included the release of mitochondrial cytochrome c and also the expression of Bcl-2, Bax and Apaf-1 [257]. Here, BAX is linked to rheumatoid arthritis.