In pathological conditions, and in particular in the inflammatory state that characterizes the articular joints in RA, the amount of lactate is greater than the amount of glucose, because the activity of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDH), the main enzymes of the glycolytic pathway, is increased in synovial cells [81]. The gene discussed is GAPDH; the disease is rheumatoid arthritis.