LRP8 and Peripheral arterial stenosis: Taken together, we interpret these data to indicate that the expression of either of the spliced forms of apoER2 is sufficient to modulate smooth muscle cell response in limiting injury-induced neointimal formation and suppress the formation of robust fibrotic neointima, but the cytoplasmic insert encoded by exon 19 is necessary to limit smooth muscle cell growth for complete protection against denudation-induced vascular occlusive disease.