The much higher GR positivity rate in adrenocortical carcinoma (88% of 25 with moderate/strong staining) than in adrenocortical adenoma (15.5% of 45 with moderate/strong staining) suggests that GR IHC could help in the otherwise challenging distinction of benign from malignant adrenocortical neoplasms (reviewed in [59]). The gene discussed is NR3C1; the disease is adrenal cortex neoplasm.