The much higher GR positivity rate in adrenocortical carcinoma (88% of 25 with moderate/strong staining) than in adrenocortical adenoma (15.5% of 45 with moderate/strong staining) suggests that GR IHC could help in the otherwise challenging distinction of benign from malignant adrenocortical neoplasms (reviewed in [59]). Here, NR3C1 is linked to adrenal cortex adenoma.