NR3C1 and Familial prostate cancer: Others have also found a link between high GR expression and unfavorable tumor phenotype in prostate cancer [65] as well as in several other cancer types such as ovarian cancer [51,66], endometrial cancer [57], salivary duct carcinoma [52], malignant melanoma [67], and squamous cell carcinoma of the esophagus [53].