Further animal studies have found suppression of adrenal hypertrophy and brain inflammation in mice that were provided a CE/TA (caffeine, EGCG, L-theanine, arginine) ratio of 2 to 8, as well as maintenance of Npas4, typically reduced in depression and anxiety, at a CE/TA ratio of 4 [7,43]. Here, NPAS4 is linked to major depressive disorder.