Our findings revealed many somatic mutated candidate biomarkers and driver genes transcriptionally associated with CRC, including CDH3, KRT80, ETV4, ESM1, FOXQ1, WNT2, CLDN1, AJUBA, NFE2L3, BEST4, CPNE7, INHBA, MTHFD1L, MMP7, PEX26, KLK6, TRIB3, KRT23, CEMIP, TRIP13, PHLPP2, SLCO4A1, MDFI, NOTUM, ENC1, VWA2, and LARGE2, from tumors versus controls, which have been experimentally confirmed to be directly involved in CRC [28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54]. This evidence concerns the gene LARGE2 and colorectal carcinoma.