As evidenced from the results in Table 1, in silico validation of the 40 highly differentially expressed highly somatic mutated genes transcriptionally associated with CRC revealed that the genes CDH3, KRT80, ETV4, ESM1, FOXQ1, WNT2, CLDN1, AJUBA, NFE2L3, BEST4, CPNE7, INHBA, MTHFD1L, MMP7, PEX26, KLK6, TRIB3, KRT23, CEMIP, TRIP13, PHLPP2, SLCO4A1, MDFI, NOTUM, ENC1, VWA2, and LARGE2, have been experimentally confirmed to be directly involved in CRC [28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54]. This evidence concerns the gene CLDN1 and colorectal carcinoma.