The pathways that facilitate initiation, progression, and migration of CRC, like Wnt/β-catenin, Notch, Hedgehog, and TGF-β (transforming growth factor-β)/SMAD, and, inclusively, those capable of activating signaling cascades, like phosphatidylinositol 3-kinase (PI3K)/AKT or RAS/rapidly accelerated fibrosarcoma (RAF), are potential sites for cancer targets and druggability [17]. Here, TGFB1 is linked to colorectal carcinoma.