Among the primary effects of TDEVs on the microenvironment are stromal effects, such as the reprogramming of the fibroblasts in the PMN to produce inflammatory cytokines and growth factors such as Stromal Cell-Derived Factor 1 (SDF1) and TGF-β, which are both accelerators of tumor migration and invasion [104,105,106]. The gene discussed is TGFB1; the disease is neoplasm.