TNFRSF11B and Familial prostate cancer: Lastly, for miRs, miR-141-3p has been isolated in EVs secreted by prostate cancer and, in one study was shown to promote osteoblast activity by inhibiting DLC1, an inhibitor of the p38MAPK pathway whose activation increases the expression of osteoprotegerin (OPG) in relation to RANKL, leading to more osteoblast activity [167].