Crucially, our demonstration that SMIR-induced spinal NTRK1 upregulation (Figure 2e–g) recapitulates patterns observed in diabetic neuropathy models reveals evolutionary conservation of this pathway—a finding substantiated by human genetic studies linking NTRK1 polymorphisms to neuropathic pain susceptibility [60,77,78]. Here, NTRK1 is linked to diabetic neuropathy.