Notably, the miRNA-mediated modulation of cholesterol biosynthesis (via HMGCR/SQLE), uptake (LDLR), efflux transporters (ABCA1/ABCG8), and master transcriptional regulators of cholesterol metabolism (SREBPs) converges to reprogram tumor growth, stemness, and therapy resistance. The gene discussed is HMGCR; the disease is neoplasm.