Accumulating evidence demonstrates that key enzymes in cholesterol biosynthesis—including HMGCR, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), Farnesyl-diphosphate farnesyltransferase 1 (FDFT1), and Squalene epoxidase (SQLE)—exhibit not only tumor-specific overexpression but also sophisticated regulation by miRNAs across malignancies [54]. This evidence concerns the gene HMGCS1 and neoplasm.