In nonalcoholic steatohepatitis (NASH)-derived HCC, androgen receptor (AR)-driven oncogene cell-cycle-related kinase (CCRK) induces the STAT3–AR axis, activates the mTORC1 cascade, and enhances MDSC recruitment and tumorigenicity [50]. The gene discussed is STAT3; the disease is metabolic dysfunction-associated steatohepatitis.