Unlike the IKZF1 germline variants that cause the common variable immunodeficiency syndrome, the IKZF1 B-ALL predisposition variants are located along the coding region of the gene (Supplementary Figure S4) and have a moderate to strong functional impact on the processes of dimerization, DNA binding, subcellular localization, cell adhesion, and drug response [78]. The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.