CDX2/UBTF rearrangement: This recently discovered B-ALL subtype is characterized by the co-occurrence of two alterations, a ~280 Kb microdeletion that relocates the CDX2 gene next to the FLT3/PAN3 gene enhancer, causing its overexpression, and a ~10 Kb microdeletion at 17q21.31 that results in the formation of UBTF::ATXN7L3 gene fusion (Supplementary Figure S2A). Here, CDX2 is linked to acute lymphoblastic leukemia.