Pharmacologic GLP-1RA administration has been shown to have various reductions in food consumption scores and an increase in perceived fullness in humans with obesity, where postprandial plasma levels of GLP-1 decreased and peptide YY (PYY) levels increased with the GLP-1RA liraglutide [130]. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.