Our transcriptomic analysis revealed significant upregulation of housekeeping genes (such as homeoboxB9) along with established gastrointestinal oncogenic markers [such as keratin (KRT)17, KRT7, mucin (MUC)5B, and KRT6B] in duodenal adenocarcinoma tissues. The gene discussed is MUC5AC; the disease is duodenal adenocarcinoma.