LDHA and autosomal dominant polycystic kidney disease: c-Myc, a transcription factor involved in cell growth and metabolic regulation, is similarly upregulated within ADPKD; it directly promotes the transcription of central glycolytic enzymes hexokinase 2 (HK2) and lactate dehydrogenase A (LDHA), thus promoting the conversion of glucose to lactate; this metabolic adaptation not only promotes energy production but also provides the biosynthetic intermediates necessary for the rapid growth of cells [36].