MYC and autosomal dominant polycystic kidney disease: The loss of polycystin function in ADPKD activates signaling pathways, including the Ras/ERK and Wnt, which can lead to increased c-Myc expression; c-Myc is known to reprogram metabolism by upregulating glycolytic enzymes and glutamine transporters, such as ASCT2, metabolic changes that promote cell proliferation in cystic epithelial cells.