In ADPKD, hyperactivation of mTORC1 drives glycolysis by increasing the expression of key glycolytic enzymes, and it upregulates hypoxia-inducible factor 1-alpha (HIF-1α), which further promotes the transcription of genes involved in glycolysis; these changes contribute to the metabolic reprogramming seen in cystic epithelial cells. The gene discussed is HIF1A; the disease is autosomal dominant polycystic kidney disease.