The hypothesis that inhibiting hypoxia-inducible factor 1-alpha (HIF-1α) could normalize the metabolic profile of cystic epithelial cells in ADPKD is supported by the results of several preclinical studies, which elucidate the role of HIF-1α in promoting glycolysis and cyst expansion, suggesting that targeting this pathway may offer therapeutic benefits. Here, HIF1A is linked to autosomal dominant polycystic kidney disease.