Exposure to 2HG in IDH-wt tumors led to a marked reduction in tumor volume (12.75 ± 8.79 mm3) and Feret diameter (4.12 ± 1.07 mm), accompanied by a decrease in surface area (35.82 ± 20.05 mm2) in comparison with IDH-wt mice. This evidence concerns the gene IDH1 and neoplasm.